In vitro metabolism of midazolam in microsomes isolated from rats treated with amprenavir for 14 days
| 4-OH Midazolam | 1′-OH Midazolam | |
|---|---|---|
| nmol/mg protein/min | ||
| Control | 0.53 ± 0.06 | 0.28 ± 0.04 |
| 139 mg | 0.39 ± 0.02 | 0.23 ± 0.04 |
| 450 mg | 0.53 ± 0.05 | 0.37 ± 0.06 |
Values represent mean ± S.E. (n = 3).