Effect of substrate on the IC50 of various compounds for CYP3A4 in HLM
| Compound | IC50 | ||
|---|---|---|---|
| Dextromethorphan | Midazolam | Testosterone | |
| μM | |||
| Ketoconazole | 0.28 | 0.07 | 0.03 |
| 3 | 2.16 | 5.43 | 4.54 |
| 4 | 1.00 | 2.29 | 2.70 |
| 5 | 0.93 | 6.78 | 6.16 |
| 10 | 1.13 | 4.91 | 6.76 |
| 12 | >30.00 | >30.00 | >30.00 |
| 15 | 3.36 | 8.58 | 15.90 |
| 18 | 0.54 | 1.86 | 0.69 |
| 22 | 11.40 | 31.6 | 13.80 |
| 23 | 0.68 | 1.87 | 2.05 |
| 25 | 1.03 | 3.76 | 5.40 |
| 26 | 0.99 | 9.98 | 1.89 |
| 28 | 31.9 | 40.4 | 26.30 |
| 39 | 2.47 | 10.6 | 6.49 |
| 44 | 0.81 | 1.34 | 0.85 |
| 45 | 16.90 | 35.00 | 4.68 |
| 52 | 37.50 | 66.40 | 11.20 |