Comparison of plasma content and excretion of total radioactivity in bile- and non-bile duct-cannulated haired male rats after an intravenous administration and a topical application of DBP
| Urine | Bile | Feces | Plasma (AUC) | |
|---|---|---|---|---|
| Intravenous administration | ||||
| Non-cannulated rats5-a | 85.2 ± 2.3 | 9.3 ± 1.0 | 1.82 ± 0.06 | |
| (n = 5) | ||||
| Cannulated rats5-b | ||||
| (n = 3) | 50.8 ± 1.35-150 | 44.5 ± 1 | 0.1 ± 0.05-150 | 1.20 ± 0.315-150 |
| Topical application | ||||
| Non-cannulated rats5-c | 17.3 ± 1.8 | 1.5 ± 0.2 | 0.125-d | |
| (n = 13) | (n = 13) | |||
| Cannulated rats5-c | ||||
| (n = 4) | 18.6 ± 0.4 | 6.7 ± 0.4 | 0.0 ± 0.05-150 | 0.11 ± 0.3 |
Values are expressed as means ± S.E.M.
↵5-150 Significant difference from non-cannulated rats dosed in the same conditions (p < 0.05).
↵5-a Values obtained 72 h after a single intravenous administration of DBP (1 mg/kg).
↵5-b Values obtained 30 h after a single intravenous administration of DBP (1 mg/kg).
↵5-c Excretion in urine or feces 24 h after a topical administration of neat DBP (10 μl/cm2, 10 cm2).
↵5-d Area under the plasma time curve of the radioactivity was calculated from the plasma concentrations reported in the Table 3.