Drug metabolism research from the past to the future
| Drug Metabolism Research | ||
|---|---|---|
| Past | Present | Future |
| Investigative Approach | ||
| Descriptive | Qualitative | Quantitative |
| In vivo | In vitro | Physiological/kinetic |
| Pharmacological | Biochemical | Genetic/molecular biological |
| Cross-species | Molecular biological | Multi-factorial systems |
| Labor intensive | Automated/predictive | Computer based |
| Individualized therapy | ||
| Analytical Techniques | ||
| Isolation | Analytical chemistry | Combinatorial modeling |
| Physical chemistry | Biochemical | Immunology/molecular biology |
| Synthesis | Modeling techniques | Mechanistic biochemistry |
| IR, UV, GC | HPLC-MS/MS, GC/EC | Genomics/proteomics |
| RIA | Computer assisted integration | |
IR, infrared; GC, gas chromatography; HPLC-MS/MS, high-performance liquid chromatography-tandem mass spectrometry; RIA, radioimmunoassay; EC, electron capture.