Warfarin | Formation of 3-Hydroxyquinidine | |
---|---|---|
Km 6-b | Vmax 6-b | |
μM | μM | pmol/min/mg |
0 | 23.7 ± 3.1 | 150 ± 5 |
25 | 24.2 ± 2.5 | 155 ± 4 |
100 | 26.4 ± 3.0 | 166 ± 5 |
200 | 22.9 ± 5.0 | 151 ± 9 |
300 | 17.6 ± 3.2 | 137 ± 6 |
350 | 18.8 ± 4.5 | 139 ± 8 |
400 | 15.6 ± 0.9 | 128 ± 2 |
450 | 15.7 ± 0.8 | 126 ± 2 |
500 | 16.4 ± 2.0 | 141 ± 4 |
550 | 17.3 ± 4.5 | 141 ± 9 |
600 | 14.1 ± 1.3 | 130 ± 3 |
700 | 17.0 ± 3.5 | 134 ± 7 |