Table 1

Kinetic parameters for the N-demethylation of (R)- and (S)-ketamine by human liver microsomes

Km1Vmax1CLint1Km2Vmax2CLint2
μM pmol/min/pmol CYP ml/min/pmol CYP μM pmol/min/pmol CYP ml/min/pmol CYP
(R)-Ketamine31.4  ± 6.23.3  ± 0.5107.0  ± 5.3495.7  ± 90.410.2  ± 0.620.9  ± 3.3
(S)-Ketamine24.1  ± 4.83.2  ± 0.5132.5  ± 17.4443.9  ± 77.710.2  ± 0.323.5  ± 4.3

Each value represents the mean ± S.D. of three independent experiments.