Effect of induction on swine cytochrome P450 activities using a liver S10 fractions
| Substrate/Metabolite | P450 Specificity | Induced (Individual Results6-a 6-b) | Control | ||
|---|---|---|---|---|---|
| S.A. | TON6-c | S.A. (Mean6-a) (N) | TON | ||
| Phenacetin | 1A | 3.548 | 13.91 | 1.195 ± 0.447 (5) | 23.90 |
| MOC | 1A | 0.190 | 0.74 | 0.035 ± 0.019 (5) | 0.70 |
| MRF | 1A | 0.015 | 0.06 | 0.003 ± 0.000 (5) | 0.06 |
| Propranolol (DIP-PPL) | lA, 2D | 0.322 | 1.26 | 0.100 ± 0.030 (5) | 2.00 |
| 7-OH-Coumarin | 2A | 0.015 | 0.06 | 0.019 ± 0.030 (5) | 0.38 |
| EtOMC | 2B | 0.193 | 0.76 | 0.030 ± 0.009 (5) | 0.60 |
| BRF | 2B | 0.047 | 0.18 | 0.003 ± 0.000 (5) | 0.06 |
| 4-OH-Diclofenac | 2C | 0.183 | 0.72 | 0.118 ± 0.038 (5) | 2.36 |
| 4-OH-Mephenytoin | 2C | 0.000 | 0.00 | 0.000 ± 0.000 (5) | 0.00 |
| Propranolol (4-OH-PPL) | 2D | 0.479 | 1.88 | 0.075 ± 0.027 (5) | 1.50 |
| 4-OH-Bufuralol | 2D | 0.240 | 0.94 | 0.297 ± 0.105 (5) | 5.94 |
| Dextromethorphan (dextrorphan) | 2D | 0.870 | 3.41 | 0.471 ± 0.130 (5) | 9.42 |
| 6-OH-Chlorzoxazone | 2E | 10.469 | 41.05 | 2.571 ± 1.151 (5) | 51.42 |
| Dextromethorphan (3-MeOMph) | 3A | 0.281 | 1.10 | 0.028 ± 0.011 (5) | 0.56 |
| 6β-OH-Testosterone | 3A | 6.307 | 24.73 | 1.231 ± 0.790 (5) | 24.6 |
| 6β-OH-Androstenedione | 3A | 4.039 | 15.84 | 0.412 ± 0.408 (4) | 8.24 |
| 6β-OH-Cortisol | 3A | 0.077 | 0.30 | 0.156 ± 0.041 (5) | 3.12 |
| Erythromycin | 3A | 0.509 | 2.00 | 0.503 ± 0.041 (5) | 10.06 |
| 12-OH Lauric acid | 4A | 6.650 | 26.08 | 0.149 ± 0.098 (5) | 2.98 |