AUC for BMO metabolites in mouse and rat hepatocytes exposed to BMO.
| Species | BMO | AUC0–45 min(nmol · min/106 cells) | |||||
|---|---|---|---|---|---|---|---|
| meso-DEB | (±)-DEB | Total DEB | BDD | GSBMO | DEB/(BDD + GSBMO) | ||
| μM | |||||||
| Mouse | 5 | 8.7 ± 4.11-a | 54.4 ± 19.2 | 63.1 ± 23.2 | 9.2 ± 1.0 | 22.0 ± 14.2 | 2.02 |
| 25 | 43.9 ± 13.1 | 153.3 ± 17.2 | 197.2 ± 27.7 | 132.9 ± 24.0 | 117.2 ± 32.2 | 0.79 | |
| 250 | 218.2 ± 28.8 | 398.0 ± 24.4 | 616.2 ± 52.8 | 908.0 ± 171.7 | 1101.3 ± 321.8 | 0.31 | |
| Rat | 5 | N.D. | 4.9 ± 0.8 | 4.9 ± 0.8 | 77.9 ± 20.0 | 26.6 ± 1.0 | 0.05 |
| 25 | 0.9 ± 0.9 | 11.6 ± 2.5 | 12.5 ± 3.4 | 435.1 ± 97.8 | 152.6 ± 9.4 | 0.02 | |
| 250 | 13.4 ± 0.5 | 66.3 ± 3.3 | 79.7 ± 2.7 | 3402.5 ± 754.8 | 1552.1 ± 205.7 | 0.02 | |
AUCs were calculated from time course experiments as described underMaterials and Methods.
N.D., not detected.
↵1-a Values are means ± S.D. for three individual hepatocyte preparations.