Rate of testosterone hydroxylation as catalyzed by hepatic microsomes from rats treated with VEH or DEX
| Treatment | Position of Hydroxylation | ||||
|---|---|---|---|---|---|
| 15β | 6β | 7α | 16α | 16β | |
| pmol/min/mg microsomal protein | |||||
| F-VEH | 21.7 ± 4.18 | 112 ± 19.9 | 579 ± 144 | 35.2 ± 11.3 | 12.4 ± 3.39 |
| F-DEX | 585 ± 10.8 | 2580 ± 265 | 1050 ± 295 | 132 ± 4.89 | 88.9 ± 8.60 |
| M-VEH | 103 ± 52.6 | 2090 ± 337 | 150 ± 42.2 | 1120 ± 315 | 30.4 ± 6.78 |
| M-DEX | 446 ± 68.8 | 4170 ± 528 | 163 ± 19.8 | 1120 ± 116 | 232 ± 123 |
Mean ± S.E., n = 3.