Table 2

Effect of serum from rabbits with an inflammatory reaction on P450 content and ability to biotransform theophylline incubated for 4 and 24 h with hepatocytes from rabbits with a turpentine-induced inflammatory reaction

	Cytochrome P450	3 MX	1 MU	1,3DMU
	nmol/mg of protein	μg/ml
4-h Incubation
H_INFLA ⁺RS_CONT	0.164 ± 0.021	0.011 ± 0.003	0.053 ± 0.005	0.710 ± 0.057
H_INFLA ⁺ RS_TIAR	0.125 ± 0.021	0.008 ± 0.002	0.035 ± 0.003^2-a	0.527 ± 0.049^2-a
24-h Incubation
H_INFLA ⁺ RS_CONT	0.135 ± 0.014	0.069 ± 0.007	0.079 ± 0.012	2.000 ± 0.187
H_INFLA ⁺ RS_TIAR	0.086 ± 0.007^2-a	0.044 ± 0.007^2-a	0.040 ± 0.010^2-a	1.280 ± 0.202^2-a

Hepatocytes from rabbits with a turpentine-induced inflammatory reaction (H_INFLA) (n = 7) were incubated with serum from control rabbits (RS_CONT), and serum from rabbits with an inflammatory reaction (RS_TIAR) (n = 7) for 4 and 24 h. Data are means ± S.E.

↵2-a p < 0.05 compared with H_INFLA + RS_CONT.