Estimates of pharmacokinetic population parameters of 4-hydroxyifosfamide (4OHIF) and ifosforamide mustard (IFM) with their relative standard error of the mean, interindividual variability, and residual variability
| 4OHIF | IFM | ||||||
|---|---|---|---|---|---|---|---|
| Parameter | Mean | RE | IIV | Parameter | Mean | RE | IIV |
| F* 4OHIF (L−1) | 0.126 | 3% | 30% | ||||
| K4OHIF(h−1) | 73.8 | 3% | 8% | KIFM (h−1) | 7.00 | 27% | 72% |
| P.E.4OHIF | 22.8% | P.E.IFM | 49.5% | ||||
| A.E.4OHIF(μM) | 0.300 | A.E.IFM (μM) | |||||
RE, relative error of the mean; IIV, interindividual variability; F*, ratio of fraction metabolized and volume of distribution of metabolite; K, first order rate constant for metabolite elimination; P.E., proportional intraindividual error; A.E., additive intraindividual error.