Table 1

Effect of selective esterase inhibitors on metabolism of HI-113 in plasma

Specificity	No Inhibitor	Paraoxon (0.1 mM) Cholinesterase and Carboxylesterase	Physostigmine (0.1 mM) Cholinesterase	EDTA (1 mM) Arylesterase
min	%
5	95	0	43	99
10	98	2	65	100
15	99	2	76	100
30	100	2	89	100
60	100	3	100	100
120	100	24	100	100

Inhibitors were preincubated with plasma at 37°C for 30 min. Data are presented as the mean of percentage of hydrolysis from two experiments.