Estimated pharmacokinetic parameter values following oral administration of HI-113 in BALB/c mice
| Measured | AUC | Cmax | t1/2 | Tmax |
|---|---|---|---|---|
| μM · min | μM | min | min | |
| Ala-d4T-MP | 1355.4 ± 288.2 | 15.6 ± 4.1 | 56.1 ± 8.5 | 9.3 ± 0.9 |
| d4T | 5928.4 ± 294.6 | 29.5 ± 0.3 | 102.6 ± 3.8 | 45.2 ± 5.2 |
Pharmacokinetic parameters in BALB/c mice (n = 4 mice per time point) are presented as the mean ± S.E.