Total P450 content (pmol/mg of protein) and CYP2C9 apoprotein levels (arbitrary units) in human liver microsomes with different CYP2C9 genotypes (mean ± S.D.)
| Genotype | n | Total P450 | CYP2C9 Apoprotein |
|---|---|---|---|
| CYP2C9*1/*1 | 9 | 471 ± 230 | 5.1 ± 3.5 |
| CYP2C9*1/*2 | 5 | 466 ± 96 | 4.7 ± 1.9 |
| CYP2C9*1/*3 | 4 | 412 ± 142 | 3.2 ± 0.8 |
| CYP2C9*2/*2 | 4 | 515 ± 356 | 4.1 ± 0.7 |
| CYP2C9*2/*3 | 2 | 544, 644 | 6.3, 5.3 |
| CYP2C9*3/*3 | 1 | 516 | 3.1 |
CYP2C9 apoprotein was quantified by immunoblotting 10 μg of microsomal protein.
n, number of individual samples.