Inhibitor | CP-611,781 (Diol) | CP-616,762 (1° OH) |
---|---|---|
Quinidine (CYP2D6 inhibitor) | ||
IC50(μM) | 0.1 | 0.07 |
Maximum inhibition (%) | 62 | 63 |
Ketoconazole (CYP3A4 inhibitor) | ||
IC50 (μM) | 0.4 | 1.5 |
Maximum inhibition (%) | 35 | 17 |
Sulfaphenazole (CYP2C9 inhibitor) | ||
IC50 (μM) | >100 | >100 |
Maximum inhibition (%) | N.D. | N.D. |
N.D., not determined.