Pharmacokinetic parameters of simvastatin in the absence or presence of itraconazole
| AUC | AUC(+I) | AUC(+I)/AUC | Cmax | Cmax(+I) | Cmax(+I)/Cmax | |
|---|---|---|---|---|---|---|
| ng · h/ml | ng/ml | |||||
| Female | 91.7 ± 8.9 | 149 ± 8 | 1.62 | 22.7 ± 4.1 | 44.5 ± 1.8 | 1.96 |
| Male | 58.3 ± 8.4 | 60.1 ± 9.4 | 1.03 | 17.0 ± 1.3 | 16.1 ± 0.7 | 0.944 |