Potential drug interactions resulting from cassette dosing
| Process | Protein Involved | Saturable? | Direct Consequence of Competitive Inhibition |
|---|---|---|---|
| Gut lumenal hydrolysis | |||
| Nonenzymatic | None | No | None |
| Enzymatic | Hydrolases | Yes | Increased F |
| Gut wall uptake | |||
| Passive | None | No | None |
| Active | Transporters | Yes | Decreased F |
| Gut wall efflux | PGP | Yes | Increased F |
| Gut wall metabolism | P450, UGT, etc. | Yes | Increased F |
| Hepatic uptake | Transporters | Yes | Decreased CL/Increased F |
| Hepatic metabolism | P450, UGT, etc. | Yes | Decreased CL/Increased F |
| Biliary efflux | Transporters | Yes | Decreased CL/Increased F |
| Plasma protein binding | Albumin, AGP | Yes | Increased CL of low clearance drugs |
| Renal glomerular filtration | None | No | None |
| Renal metabolism | P450, UGT, etc. | Yes | Decreased CL |
| Renal tubular secretion | |||
| Passive | None | No | None |
| Active | Transporters | Yes | Decreased CL |
| Renal tubular reuptake | |||
| Passive | None | No | None |
| Active | Transporters | Yes | Increased CL |
P450, cytochrome P450; PGP, P-glycoprotein; UGT, UDP-glucuronyl transferase; AGP, α1-acid glycoprotein.