Summary of cumulative recovery and urine ARE half-life of radioactivity in human subjects after oral administration of [14C]linezolid
| Subjects | Cumulative Percentage of Radioactive Dose Recovered | ARE Half-Life2-a (h), Urine | ||||||
|---|---|---|---|---|---|---|---|---|
| Urine | Feces | Total | Single-Dose | Steady-State | ||||
| Single-Dose | Steady-State | Single-Dose | Steady-State | Single-Dose | Steady-State | |||
| Mean males n = 4 | 81.4 ± 3.8 | 85.6 ± 2.9 | 12.2 ± 3.8 | 9.4 ± 3.2 | 93.6 ± 0.0 | 95.0 ± 0.8 | 4.8 ± 0.8 | 4.7 ± 1.4 |
| Mean females n = 3/42-b | 85.8 ± 2.2 | 83.5 ± 2.8 | 6.5 ± 1.4 | 10.4 ± 3.0 | 92.2 ± 0.9 | 93.9 ± 0.4 | 6.2 ± 1.0 | 5.0 ± 0.6 |
| Mean both sexes n = 7/8 | 83.3 ± 3.8 | 84.1 ± 2.8 | 9.8 ± 4.1 | 10.5 ± 2.7 | 93.0 ± 0.9 | 94.5 ± 0.8 | 5.3 ± 1.1 | 4.8 ± 1.1 |
| Mean all subjects (range)n = 15 | 83.9 ± 3.3 | 9.9 ± 3.4 | 93.8 ± 1.1 | 5.3 ± 1.3 | ||||
| (76.7–88.4) | (5.3–16.9) | (91.2–95.8) | (3.8–8.3) | |||||