Microsomal Preparation | Tramadol Metabolism Kinetics3-a | |||||||
---|---|---|---|---|---|---|---|---|
M1 Formation3-b | M2 Formation3-b | |||||||
High-Affinity Enzyme | Low-Affinity Enzyme CLint | High-Affinity Enzyme | Low-Affinity Enzyme CLint | |||||
Km | Vmax | CLint3-c | Km | Vmax | CLint3-c | |||
Pool I | 105 | 182 | 1.73 | 0.072 | 1147 | 1194 | 1.07 | 0.199 |
Pool II | 126 | 155 | 1.20 | 0.024 | 894 | 280 | 0.31 | 0.024 |
Mean of pools | 116 | 169 | 1.47 | 0.048 | 1021 | 737 | 0.69 | 0.112 |