Table 2

Total cytochrome P450 levels in hepatic microsomes from VCH, VCH-1,2-epoxide-, VCD-, or phenobarbital-treated B6C3F1 mice or Fischer-344 rats

Total Cytochrome P450
NontreatedVCHVCH-1,2-epoxideVCDPB
nmol/mg microsomal protein
Mouse2-a 0.89  ± 0.081.31  ± 0.042-c 1.48  ± 0.062-c 1.05  ± 0.181.73  ± 0.102-c
Rat2-b 0.91  ± 0.090.93  ± 0.121.00  ± 0.060.92  ± 0.081.64  ± 0.122-c
  • 2-a  n = 8 groups of microsomes were pooled from mice (4 mice/group, 16 mice total/treatment). Microsomes were prepared from individual rats (four rats per treatment).

  • 2-b  n = 8 separate rats.

  • 2-c  Significantly different (p < 0.05) from control.