Densitometric analyses of Western blots (Fig. 2) using microsomes from Fischer-344 rats treated with VCH (7.5 mmol/kg i.p. for 10 days), VCH-1,2-epoxide (1.75 mmol/kg i.p. for 10 days), or VCD (0.4 mmol/kg i.p. for 10 days), as previously described under Materials and Methods. Densitometric analyses have been normalized to control (i.e., nontreated rats). Blots represent microsomes from individual rats (four rats per treatment group). All Western blots were performed four times per antibody probed using different sets of microsomes.