PK parameters (CV%) of COC, NORC, and BE administered as parent compounds using model 1
| COC (i.v./p.o.) | NORC (i.v.) | BE (i.v.) | |
|---|---|---|---|
| Parameters for open two-compartment model | |||
| Vc(l/kg) | 2.50 (14.2) | 2.90 (1.71) | 0.52 (6.33) |
| Vss(l/kg) | 4.95 (9.21) | 5.77 (2.34) | 1.07 (2.24) |
| Cl (l/h/kg) | 9.86 (4.85) | 11.5 (0.23) | 1.36 (1.41) |
| MRT (min) | 30.1 (5.42) | 30.1 (2.13) | 47.4 (1.50) |
| k1, 0(min−1) | 0.066 (10.7) | 0.066 (1.50) | 0.044 (5.81) |
| k1, 2(min−1) | 0.042 (17.9) | 0.072 (5.74) | 0.073 (16.6) |
| k2, 1(min−1) | 0.043 (9.72) | 0.072 (7.09) | 0.069 (9.28) |
| α (min−1) | 0.13 (12.0) | 0.18 (5.03) | 0.17 (11.6) |
| t 1/2α (min) | 5.4 | 3.8 | 4.1 |
| β (min−1) | 0.022 (5.69) | 0.026 (3.51) | 0.018 (2.08) |
| t 1/2β (min) | 31.7 | 26.7 | 38.7 |
| A (μg/ml) | 0.58 (17.2) | 0.49 (0.80) | 1.26 (9.02) |
| B (μg/ml) | 0.14 (7.83) | 0.20 (5.47) | 0.66 (4.15) |
| Parameters for the absorption model | |||
| k a(min−1) | 0.059 (6.93) | ||
| F (%) | 3.77 (4.84) | ||
| MAT (min) | 16.9 | ||
| AIC | −1.81 | −1.58 | −1.56 |
MAT, mean absorption time.