4-HA induced hepatotoxicity in in vivo
| Condition (Dose i.p.) | Plasma |
|---|---|
| AST (Fold Control) | |
| None | 1.0 ± 0.1 |
| 4-HA | |
| " (200 mg/kg) | 6.8 ± 0.8 |
| " (300 mg/kg) | 15.9 ± 1.7 |
| " (400 mg/kg) | 18.2 ± 1.6 |
Drugs were administered to 30 g male Sprague-Dawley mice (n = 9 per treatment). Plasma transaminase levels (AST) were determined from blood samples taken 5 h post-treatment. The plasma AST level for control mice was 835 SF units/mL.