Pharmacokinetic parameters for NNN and metabolites in the patas monkey
| t1/2 | CLR | AUC Ratio (Metabolite/NNN) | tmax | |
|---|---|---|---|---|
| min | ml/min | min | ||
| Hydroxy acid | 42.1 ± 16.31-a | 15.6 ± 4.5 | 0.80 ± 0.28 | 30 ± 0 |
| Norcotinine | 198.7 ± 128.0 | 1.7 ± 0.8 | 1.46 ± 1.02 | 80 ± 35 |
| 3′-Hydroxynorcotinine | 174 ± 26.8 | 23.2 ± 13.8 | 0.23 ± 0.1 | 40 ± 17 |
| Norcotinine-1N-oxide | 162.4 ± 54.4 | 35.3 ± 23.9 | 0.16 ± 0.08 | 90 ± 30 |
| NNN | 26.8 ± 12.7 | 0.27 ± 0.24 | 3.0 ± 1.7 |
↵1-a Mean ± S.D. (n = 3).