0–6 h | 6–24 h | 24–48 h | 48–72 h | Over 72 h | |
---|---|---|---|---|---|
CAP | |||||
Rat | 3.5 ± 0.7 | 0.79 ± 0.44 | 0.02 ± 0.03 | 4.3 ± 1.0 | |
LD mice | 10 ± 33-150 | 1.4 ± 0.43-150 | 0.09 ± 0.083-150 | 0.04 ± 0.06 | 12 ± 23-150 |
HD mice | 3.3 ± 3.83-151 | 3.5 ± 0.63-151 | 0.73 ± 0.263-151 | 0.19 ± 0.17 | 7.7 ± 2.63-151 |
5′-DFCR | |||||
Rat | 37 ± 15 | 25 ± 6 | 2.9 ± 1.0 | 0.58 ± 0.70 | 65 ± 11 |
LD mice | 14 ± 23-150 | 1.7 ± 0.83-150 | 0.09 ± 0.083-150 | 0.08 ± 0.073-150 | 16 ± 13-150 |
HD mice | 5.4 ± 5.43-151 | 6.9 ± 1.93-151 | 1.3 ± 0.73-151 | 0.47 ± 0.373-151 | 14 ± 2 |
5′-DFUR | |||||
Rat | 1.9 ± 1.6 | 1.2 ± 0.3 | 0.16 ± 0.09 | 0.06 ± 0.10 | 3.3 ± 2.1 |
LD mice | 23 ± 23-150 | 6.2 ± 1.73-150 | 0.45 ± 0.263-150 | 0.27 ± 0.34 | 30 ± 13-150 |
HD mice | 6.1 ± 5.13-151 | 13 ± 33-151 | 3.5 ± 1.93-151 | 0.88 ± 0.68 | 23 ± 23-151 |
5-FU | |||||
Rat | 0.01 ± 0.02 | 0.01 ± 0.02 | 0.02 ± 0.03 | 0.06 ± 0.10 | 0.10 ± 0.12 |
LD mice | 0.02 ± 0.03 | 0.10 ± 0.18 | 0.01 ± 0.02 | 0.06 ± 0.07 | 0.19 ± 0.24 |
HD mice | 0.01 ± 0.01 | 0.08 ± 0.02 | 0.03 ± 0.01 | 0.02 ± 0.01 | 0.14 ± 0.02 |
5-FUH2 | |||||
Rat | |||||
LD mice | 0.12 ± 0.11 | 0.07 ± 0.06 | 0.19 ± 0.17 | ||
HD mice | 0.05 ± 0.06 | 0.15 ± 0.02 | 0.06 ± 0.04 | 0.26 ± 0.08 | |
FUPA + FBAL3-a | |||||
Rat | 1.5 ± 0.5 | 2.4 ± 1.1 | 0.35 ± 0.12 | 0.10 ± 0.17 | 4.4 ± 1.3 |
LD mice | 11 ± 13-150 | 11 ± 0.53-150 | 1.2 ± 0.43-150 | 0.69 ± 0.91 | 24 ± 23-150 |
HD mice | 3.0 ± 2.83-151 | 14 ± 23-151 | 6.2 ± 2.93-151 | 1.2 ± 0.6 | 24 ± 1 |
5-FC + 5-FCOH | |||||
Rat | 0.14 ± 0.04 | 0.47 ± 0.35 | 0.61 ± 0.42 | ||
LD mice | 0.06 ± 0.08 | 0.22 ± 0.17 | 0.28 ± 0.22 | ||
HD mice | 0.07 ± 0.04 | 0.50 ± 0.073-151 | 0.19 ± 0.08 | 0.01 ± 0.01 | 0.77 ± 0.193-151 |
F− | |||||
Rat | 0.64 ± 0.26 | 1.8 ± 0.4 | 1.8 ± 1.3 | 1.5 ± 0.5 | 5.7 ± 1.3 |
LD mice | 0.64 ± 0.37 | 1.0 ± 0.43-150 | 1.2 ± 0.7 | 0.64 ± 0.693-150 | 3.4 ± 0.73-150 |
HD mice | 0.05 ± 0.063-151 | 0.73 ± 0.25 | 0.48 ± 0.153-151 | 0.48 ± 0.06 | 1.7 ± 0.23-151 |
Total | |||||
Rat | 45 ± 17 | 31 ± 8 | 5.3 ± 1.7 | 2.3 ± 0.7 | 84 ± 10 |
LD mice | 59 ± 6 | 22 ± 3 | 3.0 ± 0.7 | 1.8 ± 1.2 | 86 ± 1 |
HD mice | 18 ± 173-151 | 39 ± 43-151 | 13 ± 63-151 | 3.3 ± 1.9 | 73 ± 63-151 |
Data are expressed as % a.d. Data in bold characters represent the main metabolite in each urine fraction or in total collection.