Pharmacokinetic parameters of FBZSO, FBZ, and FBZSO2 following oral administration of fenbendazole (10 mg/kg) with or without food, and with or without piperonyl-butoxide (PB) (63 mg/kg).
| FBZSO | FBZCmax (μg/ml) | FBZSO2 | |
|---|---|---|---|
| +Food | 0.01 ± 0.00 | 0.04 ± 0.01 | 0.09 ± 0.02 |
| −Food | 0.03 ± 0.01 | 0.02 ± 0.01 | 0.04 ± 0.02 |
| +Food + PB | 0.13 ± 0.07 | 0.37 ± 0.10 | 0.11 ± 0.03 |
| −Food + PB | 0.04 ± 0.00 | 0.16 ± 0.02 | 0.05 ± 0.01 |
| AUC (μg · h/ml) | |||
| +Food | 0.15 ± 0.06 | 0.44 ± 0.01 | 1.47 ± 0.19 |
| −Food | 1.87 ± 0.60 | 0.32 ± 0.11 | 1.20 ± 0.49 |
| +Food + PB | 2.08 ± 0.99 | 5.81 ± 1.96 | 1.44 ± 0.33 |
| −Food + PB | 0.82 ± 0.22 | 3.51 ± 0.40 | 1.29 ± 0.27 |
| MRT (h) | |||
| +Food | 7.53 ± 1.28 | 11.40 ± 1.63 | 18.77 ± 1.70 |
| −Food | 22.94 ± 7.35 | 11.68 ± 3.29 | 30.86 ± 6.00 |
| +Food + PB | 13.56 ± 2.44 | 12.63 ± 1.97 | 20.19 ± 1.72 |
| −Food +PB | 21.05 ± 2.53 | 17.51 ± 1.45 | 28.10 ± 7.10 |