Summary of mean (S.D.) pharmacokinetic parameters, ratios, and 90% confidence intervals for the active metabolite Ro 64-0802 following a single oral dose of 150 mg of oseltamivir given alone, with cimetidine (400 mg q.i.d.), or with probenecid (500 mg q.i.d.) in healthy volunteers (n = 18)
| Ro 64-0802 Parameter | Regimen A (alone) Mean (S.D.) | Regimen B (with Cimetidine) | Regimen C (with Probenecid) | ||
|---|---|---|---|---|---|
| Mean (S.D.) | Ratio B/A (90% CI) | Mean (S.D.) | Ratio C/A (90% CI) | ||
| % | % | ||||
| C max(ng/mL) | 587 (136) | 599 (198) | 102 (88, 116)1-a | 1093 (325) | 186 (173, 200) |
| AUC∞(ng · h/mL) | 6597 (1225) | 6992 (1850) | 106 (83, 129) | 16603 (5091) | 252 (229, 275) |
| t max(h) | 4.5 (1.1) | 4.1 (0.8) | N.A.1-b | 5.3 (1.1) | N.A. |
| fe (%) | 71.5 (16.7) | 69.6 (10.9) | N.A. | 78.0 (25.8)1-c | N.A. |
| CLR(l/h) | 15.7 (4.4) | 15.0 (4.4) | N.A. | 7.5 (3.9)1-c | N.A. |