Table 3

Summary of mean (S.D.) values, ratios, and 90% confidence intervals of steady-state (oseltamivir 75 mg b.i.d.) pharmacokinetic parameters of Ro 64-0802 (active metabolite) in the absence (Regimen B) and presence (Regimen C) of amoxicillin (500 mg) in healthy volunteers (n = 12)

Ro 64-0802 ParameterRegimen B Mean (S.D.)Regimen C Mean (S.D.)Ratio C/B (90% CI)
%
C max(ng/mL)389 (59)397 (74)102 (98, 106)3-a
AUC0–12(ng · hr/mL)3438 (439)3330 (425)96.8 (95, 99)3-a
t max(h)3.7 (1.1)3.3 (1.3)N.A.3-b
fe (%)83.1 (6.2)84.9 (6.2)N.A.
CLR(l/h)16.8 (2.5)17.7 (2.5)N.A.

  • CI, confidence interval.

  • ↵3-a  Ratio of means (log transformed) of the 90% CI were within the 80 to 125% bioequivalence range.

  • ↵3-b  Not applicable.