Table 1

Pharmacokinetic parameters for steady-state tissue distribution of GPFX in rats

TissuesKp1-akel1-b
ml/g min−1
Lung15.1  ± 0.48.55
Liver8.55  ± 0.170.0667
Kidney11.2  ± 0.90.421
Pancreas13.6  ± 0.50.171
Spleen11.1  ± 0.80.119
Thymus6.34  ± 0.170.259
Heart3.87  ± 0.201.41
Stomach4.52  ± 0.490.162
Muscle2.64  ± 0.150.0946
Small intestine7.66  ± 0.830.489
Large intestine3.67  ± 0.750.384
Testis0.753  ± 0.0910.478
Brain0.239  ± 0.0038.98

Each value represents the mean ± S.E. of three different rats.

  • ↵1-a  Tissue-to-blood concentration ratio. Kp was calculated by dividing the tissue concentration (micrograms per gram of tissue) by the plasma concentration (micrograms per milliliter of plasma).

  • ↵1-b  Elimination rate constant in each tissue compartment obtained by dividing blood flow rate byKp.