Fraction escaping extraction by the liver (FH), gastrointestinal tract (FGI), splanchnic region (FSpl), lungs (FLu) and kidneys (FR) after three sequentially escalated intravenous infusions of amifostine
| Dose Rate | FH | FGI | FSpl | FLu | FR |
|---|---|---|---|---|---|
| μmol/min/kg | |||||
| 0.125 | 0.111 ± 0.056 | 0.567 ± 0.024 | 0.165 ± 0.109 | 0.931 ± 0.089 | 0.435 ± 0.110 |
| AB | |||||
| 0.500 | 0.117 ± 0.066 | 0.877 ± 0.040 | 0.111 ± 0.061 | 0.922 ± 0.072 | 0.427 ± 0.051 |
| A | |||||
| 1.00 | 0.084 ± 0.027 | 0.849 ± 0.109 | 0.094 ± 0.041 | 0.936 ± 0.068 | 0.432 ± 0.047 |
| B | |||||
| Significance2-a(n) | 0.590 (5) | <0.001 (5) | 0.138 (10) | 0.926 (10) | 0.987 (5) |
Data are reported as mean ± S.D. (n = 5–10 dogs).
↵2-a P values were determined by ANOVA with repeated measures. For a given parameter, mean values with the same capital letter are significantly different (Tukey's test; α = 0.05).