Table 4

Plasma concentrations of amifostine perfusing the gastrointestinal tract, splanchnic region or kidneys (equivalent to C_CA), lungs (C_PA), and liver (C_ave) after three sequentially escalated intravenous infusions of amifostine

Dose Rate	C_CA	C_PA	C_ave	Significance^4-a
μmol/min/kg		μM
0.125	2.7 ± 1.0	2.9 ± 1.2	1.6 ± 0.4	0.066
0.500	14.7 ± 4.2	15.8 ± 4.6	14.2 ± 4.2	0.759
1.00 (n)	27.8 ± 8.2 (10)	29.2 ± 8.8 (10)	29.0 ± 8.5 (5)	0.924

Data are reported as mean ± S.D. (n = 5–10 dogs).
↵4-a values were determined by ANOVA with repeated measures.