Summary of predicted (in vitro) and observed (in vivo) clearance in monkey
| Compound | In Vivo Clearance | In Vitro Clearance | ||
|---|---|---|---|---|
| Fresh | Sandwich-cultured | Cryopreserved | ||
| ml/min/kg | μl/min/million cells | |||
| 2 | 18 | 11 | 13 | 16 |
| 5 | 9.2 | 1.8 | 2.7 | 3.3 |
| 6 | 4.5 | 2.4 | 1.7 | 4.5 |
| 7 | 10 | 3.3 | 4.4 | 5.8 |
| 9 | 49 | 27 | 36 | 44 |
| 10 | 24 | 17 | 21 | 48 |
| 12 | 8.4 | 9.4 | 25 | 16 |
| 13 | 5.2 | 13 | 23 | 12 |
| 14 | 5.0 | 11 | 16 | 5.4 |
| 15 | 11 | 3.7 | 7.4 | 6.3 |
| 16 | 1.2 | 2.2 | 5.0 | 4.0 |
| 18 | 13 | 20 | 20 | 25 |
| 19 | 11 | 8.2 | 11 | 7.9 |
| 20 | 0.75 | 0.36 | 1.1 | 0.14 |
| 21 | 18 | 16 | 21 | 30 |
| 22 | 3.5 | 2.2 | 6.1 | 4.2 |
| 24 | 18 | 14 | 17 | 21 |
| 26 | 13 | 4.3 | 9.4 | 7.8 |
| 27 | 4.3 | 7.6 | 8.7 | 5.2 |
| 30 | 6.0 | 9.0 | 15 | 16 |
| 32 | 0.3 | 2.9 | 2.7 | 1.8 |
| 34 | 13 | 12 | 22 | 13 |
| 35 | 12 | 7.2 | 6.1 | 7.0 |
| 36 | 5.4 | 13 | 22 | 13 |
| 37 | 14 | 26 | 34 | 24 |
| 38 | 17 | 29 | 45 | 30 |