Parameters | Units | High-Dose Study | Low-Dose Study | ||
---|---|---|---|---|---|
F-344 | S-D | F-344 | S-D | ||
K | h−1 | 0.013 ± 0.003 | 0.008 ± 0.002 | 0.011 ± 0.002 | 0.008 ± 0.002 |
t 1/2 | h | 52 ± 11 | 88 ± 17 | 65 ± 14 | 86 ± 18 |
AUC | ng · h/ml | 9800 ± 1400 | 3300 ± 320 | 3600 ± 580 | 2500 ± 280 |
C max | ng/ml | 110 ± 5 | 41 ± 1 | 44 ± 6 | 27 ± 1 |
T max | h | 16 ± 1 | 6.0 ± 0.2 | 2.6 ± 0.3 | 4.8 ± 0.3 |