Subject No. | P14-a | *24-b | *34-c | *44-d | *54-e | *64-f | Age | Height | Weight |
---|---|---|---|---|---|---|---|---|---|
yr | cm | kg | |||||||
1 | + | +++ | + | + | 26 | 169 | 72 | ||
2 | ++ | ++ | + | + | 29 | ||||
3 | + | +++ | + | + | 25 | 168 | 55 | ||
4 | + | +++ | + | + | 26 | 165 | 55 | ||
5 | +++ | ++ | + | + | 26 | 174 | 80 | ||
6 | + | +++ | + | + | 31 | 177 | 72 | ||
7 | ++ | ++ | + | + | 24 | 171 | 62 | ||
8 | ++ | + | + | + | 26 | ||||
9 | ++ | ++ | + | + | 25 | 175 | 78 | ||
10 | ++ | ++ | + | + | 28 | 178 | 66 | ||
11 | + | +++ | + | + | 28 | 173 | 65 | ||
12 | ++ | ++ | + | + | 22 | 177 | 67 | ||
13 | + | +++ | + | + | 23 | ||||
14 | + | +++ | + | + | 23 | 170 | 61 | ||
15 | ++ | ++ | + | + | 25 | 172 | 60 | ||
16 | +++ | + | + | + | 25 | 171 | 60 | ||
17 | ++ | ++ | + | + | 25 | 167 | 53 | ||
18 | ++ | +++ | + | + | 25 | 163 | 62 | ||
19 | + | +++ | + | + | 25 | 175 | 94 | ||
20 | +++ | + | + | + | 23 | 180 | 71 | ||
21 | + | +++ | + | + | 25 | 168 | 57 | ||
22 | ++ | ++ | + | + | 26 | ||||
23 | + | +++ | + | + | 25 | ||||
24 | + | +++ | + | + | 25 | ||||
25 | + | +++ | + | ++ | 22 | ||||
26 | ++ | ++ | + | + | 26 | ||||
27 | ++ | ++ | + | + | 25 | 172 | 71 | ||
28 | ++ | +++ | + | + | 25 | ||||
29 | ++ | ++ | + | + | 26 | 178 | 82 | ||
30 | ++ | ++ | + | + | 24 | 177 | 75 | ||
31 | ++ | ++ | + | + | 23 | ||||
32 | + | +++ | + | + | 22 | 187 | 81 | ||
33 | + | +++ | + | + | 23 | ||||
34 | + | +++ | + | + | 24 | 177 | 64 | ||
35 | + | +++ | + | + | 23 | 178 | 56 | ||
36 | + | +++ | + | + | 23 | 167 | 58 | ||
37 | ++ | ++ | + | + | 23 | 176 | 58 | ||
38 | ++ | ++ | + | + | 22 | ||||
39 | + | +++ | + | + | 24 | 170 | 55 | ||
40 | + | +++ | + | + | 25 | ||||
41 | + | +++ | ++ | + | 22 | ||||
42 | ++ | ++ | + | + | 24 | 172 | 66 |
Demographic data were collected only from the volunteers that participated in the midazolam study. None of the volunteers in the midazolam study had smoking or alcohol drinking habits.
↵4-a CYP3AP1 genotype: +, A/A; ++, A/G; +++, G/G.
↵4-b CYP3A5*2 genotype: all volunteers are C/C wild type.
↵4-c CYP3A5*3 genotype: +, A/A; ++, A/G; +++, G/G.
↵4-d CYP3A5*4 genotype: +, A/A; ++, A/G; G/G was not detected.
↵4-e CYP3A5*5 genotype: +, T/T; ++, T/C; C/C was not detected.
↵4-f CYP3A5*6 genotype: all volunteers are A/A wild type.