Table 4

Genotypes and demographic data of the volunteers

Subject No.P14-a*24-b*34-c*44-d*54-e*64-fAgeHeightWeight
yr cm kg
1 + +++ + + 2616972
2 ++ ++ + + 29
3 + +++ + + 2516855
4 + +++ + + 2616555
5 +++ ++ + + 2617480
6 + +++ + + 3117772
7 ++ ++ + + 2417162
8 ++ + + + 26
9 ++ ++ + + 2517578
10 ++ ++ + + 2817866
11 + +++ + + 2817365
12 ++ ++ + + 2217767
13 + +++ + + 23
14 + +++ + + 2317061
15 ++ ++ + + 2517260
16 +++ + + + 2517160
17 ++ ++ + + 2516753
18 ++ +++ + + 2516362
19 + +++ + + 2517594
20 +++ + + + 2318071
21 + +++ + + 2516857
22 ++ ++ + + 26
23 + +++ + + 25
24 + +++ + + 25
25 + +++ + ++ 22
26 ++ ++ + + 26
27 ++ ++ + + 2517271
28 ++ +++ + + 25
29 ++ ++ + + 2617882
30 ++ ++ + + 2417775
31 ++ ++ + + 23
32 + +++ + + 2218781
33 + +++ + + 23
34 + +++ + + 2417764
35 + +++ + + 2317856
36 + +++ + + 2316758
37 ++ ++ + + 2317658
38 ++ ++ + + 22
39 + +++ + + 2417055
40 + +++ + + 25
41 + +++ ++ + 22
42 ++ ++ + + 2417266

Demographic data were collected only from the volunteers that participated in the midazolam study. None of the volunteers in the midazolam study had smoking or alcohol drinking habits.

  • 4-a  CYP3AP1 genotype: +, A/A; ++, A/G; +++, G/G.

  • 4-b  CYP3A5*2 genotype: all volunteers are C/C wild type.

  • 4-c  CYP3A5*3 genotype: +, A/A; ++, A/G; +++, G/G.

  • 4-d  CYP3A5*4 genotype: +, A/A; ++, A/G; G/G was not detected.

  • 4-e  CYP3A5*5 genotype: +, T/T; ++, T/C; C/C was not detected.

  • 4-f  CYP3A5*6 genotype: all volunteers are A/A wild type.