Table 1

Kinetic and binding data for experiments using 0.25, 1, and 4 mg/ml rat liver microsomes

Compound	Data Using 0.25 mg/ml Microsomes		Data Using 1 mg/ml Microsomes		Data Using 4 mg/ml Microsomes
Compound	CL_int/μl min⁻¹ mg protein⁻¹	fu_inc	CL_int,u μl min⁻¹ mg protein⁻¹	CL_int/μl min⁻¹ mg protein⁻¹	fu_inc	CL_int,u μl min⁻¹ mg protein⁻¹	CL_int/μl min⁻¹ mg protein⁻¹	fu_inc	CL_int,uμl min⁻¹ mg protein⁻¹
2-Ethoxybenzamide	58 ± 6	0.97 ± 0.07	60 ± 8	43 ± 4	0.98 ± 0.02	44 ± 4	31 ± 5	0.95 ± 0.02	32 ± 5
Albendazole	128 ± 13	0.80 ± 0.08	161 ± 23	122 ± 13	0.56 ± 0.08	217 ± 38	52 ± 18	0.24 ± 0.02	222 ± 80
Amiodarone	115 ± 16	0.006 ± 0.003	19252 ± 10567	28 ± 5	0.002 ± 0.001	12190 ± 6247	3 ± 1	<0.001
Astemizole	554 ± 40	0.076 ± 0.04	7317 ± 4699	160 ± 33	0.012 ± 0.002	13290 ± 3198	79 ± 23	0.008 ± 0.004	10373 ± 5927
Betaxolol	68 ± 15	0.89 ± 0.09	76 ± 19	58 ± 9	0.62 ± 0.05	93 ± 17	30 ± 10	0.35 ± 0.02	84 ± 29
Bumetanide	157 ± 6	0.95 ± 0.04	164 ± 9	122 ± 7	0.92 ± 0.03	132 ± 9	121 ± 21	0.83 ± 0.19	145 ± 41
Cerivastatin	27 ± 3	0.87 ± 0.10	31 ± 5	13 ± 3	0.65 ± 0.03	20 ± 5	5 ± 1	0.42 ± 0.04	11 ± 3
Clozapine	427 ± 127	0.54 ± 0.07	789 ± 255	244 ± 9	0.26 ± 0.07	939 ± 240	87 ± 9	0.08 ± 0.01	1038 ± 179
Glyburide	200 ± 12	0.93 ± 0.07	216 ± 20	160 ± 33	0.82 ± 0.03	195 ± 41	79 ± 23	0.64 ± 0.04	123 ± 37
Indapamide	24 ± 14	0.92 ± 0.15	27 ± 16	41 ± 2	0.96 ± 0.03	43 ± 3	20 ± 4	0.81 ± 0.04	25 ± 5
Isradipine	84 ± 11	0.58 ± 0.05	146 ± 23	45 ± 6	0.34 ± 0.04	132 ± 22	< 3	0.08 ± 0.06
Metyrapone	55 ± 20	0.97 ± 0.03	57 ± 21	41 ± 9	0.99 ± 0.03	41 ± 9	16 ± 4	0.92 ± 0.05	17 ± 4
Oxaprozin	117 ± 7	0.90 ± 0.09	130 ± 15	75 ± 4	0.87 ± 0.04	85 ± 6	56 ± 4	0.77 ± 0.01	72 ± 5

Data are the mean ± 95% confidence interval for four replicate measurements