ALDH activity for different aldehydes by ALDH2 genotypes in the 700g supernatant of human liver
| Substrate | ALDH2*1/*1 | ALDH2*1/*2 (%) |
|---|---|---|
| nmol/min/mg protein | ||
| Acetaldehyde | 24.30 ± 5.51 | 3.09 ± 1.55 (13)4-a |
| n-Butyraldehyde | 34.43 ± 7.29 | 7.27 ± 6.38 (21)4-a |
| Heptaldehyde | 49.69 ± 9.81 | 32.50 ± 9.72 (65)4-a |
| Decylaldehyde | 50.75 ± 10.78 | 42.22 ± 10.77 (83) |
| Benzaldehyde | 24.14 ± 3.63 | 22.18 ± 7.84 (92) |
Data represent the mean ± S.D. of 31 and 8 subjects with ALDH2*1/*1 and ALDH2*1/*2, respectively. Values in parentheses are percentages relative to activity in ALDH2*1/*1 subjects. Assays were performed at a substrate concentration of 10 μM.
↵4-a P < 0.05 compared with ALDH2*1/*1 group.