Effects of cigarette smoking, drinking alcohol, and sex on ALDH activity in liver mitochondria from ALDH2*1/*1 genotype subjects
| n | γ-GTP5-a | ALDH Activity | ||
|---|---|---|---|---|
| Acetaldehyde | Benzaldehyde | |||
| nmol/min/mg protein | ||||
| Males | ||||
| Nonsmoker nondrinker | 8 | 11 ± 8 | 33.63 ± 5.88 | 7.60 ± 2.45 |
| Smoker and drinker | 10 | 20 ± 34 | 35.35 ± 5.85 | 7.36 ± 2.42 |
| Female | ||||
| Nonsmoker nondrinker | 11 | 9 ± 7 | 36.28 ± 5.72 | 8.05 ± 2.29 |
The activity was determined at substrate concentration of 10 μM, and data represent the mean ± S.D. of the indicated number of subjects.
↵5-a Results of serum γ-GTP are also determined to identify any hepatic damage caused by drinking alcohol or other factors. One case in each of the nonsmoker nondrinker and smoker and drinker groups showed the highest value of 239 and 117, respectively. These two values were not included in the mean of the index.