Pharmacokinetic parameters of JANEX-1 and JANEX-1-M in mice
| Dose | Vc | Vss | CLs | AUC | Cmax | t1/2 | |
|---|---|---|---|---|---|---|---|
| mg/kg | ml/kg | ml/kg | ml/h/kg | μM · h | μM | min | |
| JANEX-1 | i.v., 40 | 745.7 ± 40.7 | 857.7 ± 80.8 | 1458.0 ± 258.6 | 94.8 ± 18.4 | 181.0 ± 10.0 | 77.1 ± 10.2 |
| JANEX-1-M | i.v., 40 | 429.4 ± 206.1 | 811.6 ± 336.0 | 5525.1 ± 1926.2 | 27.5 ± 8.0 | 383.3 ± 164.4 | 33.0 ± 20.1 |
Pharmacokinetic parameters are expressed as mean ± S.D. (n = 4 mice per time point).
AUC, area under the curve.