Plasma pharmacokinetic parameters (mean ± S.E.M.) of LY354740 in rats (n = 3 male rats) following a 5-mg/kg intravenous bolus or 30-mg/kg oral dose
| Pharmacokinetic Parameters | i.v. | p.o. |
|---|---|---|
| C max (μg/ml) | 18.1 ± 0.8 | 0.51 ± 0.03 |
| AUC0–12(μg · h/ml) | 7.5 ± 0.4 | 4.7 ± 0.6 |
| AUC0–∞(μg · h/ml) | 7.6 ± 0.4 | 4.8 ± 0.6 |
| t 1/2 (h) | 3.2 ± 0.2 | 5.1 ± 0.6 |
| CLp/F (ml/min/kg) | 11.1 ± 0.6 | 11.2 ± 1.3 |
| MRT (h) | 1.9 ± 0.1 | 9.0 ± 1.7 |
| Vdss(l/kg) | 1.2 ± 0.1 | — |
| VdB(l/kg) | 3.2 ± 0.4 | — |
| T max(h) | —1-a | 2.0 ± 0.0 |
| F (%) | — | 10.5 |
↵1-a Not determined.