Estimated pharmacokinetic parameters used to calculate radiation absorbed dose from selected tissues in rats following a single oral 30-mg/kg dose of [14C]LY354740 monohydrate
| Tissue | AUC0–t | AUC0–∞ | Cmax | Tmax | t1/2 | Radiation Absorbed Dose5-a |
|---|---|---|---|---|---|---|
| μg · h/g | μg/g | h | mRad | |||
| Harderian gland | 12.13 | 104.05 | 3.59 | 4.00 | NR | NC |
| Intestinal wall | 193.44 | 254.68 | 40.95 | 4.00 | 3.97 | 5.52 |
| Kidney5-b | 3667.28 | 3673.56 | 706.34 | 4.00 | 2.41 | 29.14 |
| Liver | 50.70 | 62.74 | 8.08 | 4.00 | 4.10 | 0.55 |
| Thymus5-c | 94.07 | 167.90 | 6.30 | 8.00 | 16.14 | NC |
NC, not calculated; NR, not reported due to limited data points.
↵5-a Calculated for a 100 μCi dose of [14C]LY354740 in man.
↵5-b High tissue concentration value from Table 4 used for calculations.
↵5-c QWBA data may not always be robust enough to provide definitive pharmacokinetic parameters in every tissue. For thymus, the t1/2 is estimated as the sampling interval is similar to the reported value.