Table 1

Effect of p.o. or i.v. administration of bergamottin (0.1 mg/kg) on diazepam (10 mg) pharmacokinetics in beagle dogs

	AUC_(0–TLDC)	C_max	t½
	ng · h/ml	ng/ml	h
Control^1-a	6.90 ± 6.3	15.90 ± 11.3	N.D.
p.o. bergamottin	24.69 ± 3.3^1-165	41.60 ± 7.0^1-165	0.50 ± 0.3
i.v. bergamottin	21.12 ± 11.0^1-160	36.76 ± 20.4^1-150	0.62 ± 0.6

Male beagle dogs were administered a single dose of bergamottin or vehicle p.o. or i.v. followed by p.o. administration of a 10-mg diazepam tablet. Plasma levels of diazepam were measured by LC/MS/MS to determine pharmacokinetic parameters, as described underMaterials and Methods.

N.D., not determined due to insufficient data points.
↵1-150 p < 0.05,
↵1-160 p< 0.01,
↵1-165 p < 0.001 as compared to control.
↵1-a n = 4 for control;n = 5 for bergamottin-treated.