Sample | % Recovery of the Administered Dose as: | |||||
---|---|---|---|---|---|---|
DMN-AG-S | DMN-PG | DMN-S | DMN-AG | DMN | Total | |
Bile | ||||||
0–1 h | 2.57 ± 2.4 | 5.47 ± 2.2 | 2.56 ± 1.7 | 9.45 ± 4.1 | 0.68 ± 0.3 | 20.7 ± 10.2 |
1–2 h | 1.22 ± 0.7 | 0.71 ± 0.4 | 0.37 ± 0.1 | 0.88 ± 0.9 | 0.06 ± 0.07 | 3.25 ± 1.9 |
2–6 h | < | < | < | < | < | < |
0–6 h | 3.80 ± 3.1 | 6.19 ± 2.4 | 2.94 ± 1.6 | 10.3 ± 4.8 | 0.74 ± 0.3 | 23.9 ± 11.8 |
Urine | ||||||
0–6 h | < | < | 46.4 ± 3.2 | < | 9.5 ± 1.3 | 56.0 ± 1.9 |
Total Bile + Urine | 3.80 ± 3.1 | 6.19 ± 2.4 | 49.3 ± 4.6 | 10.3 ± 4.8 | 10.2 ± 1.0 | 79.9 ± 12.9 |
The dose was 50 mg of DMN/kg; results are means ± S.D.;n = 4.
<, below the detection limit of the assay.