Table 1

Pharmacokinetic parameters of OA after a single intravenous administration of [14C]OA (0.25 mg/kg) to intact and biliary fistula dogs

Pharmacokinetic ParametersIntactBiliary Fistula
AUC0–72(ng · hr/ml)1672.1  ± 158.31913.1 ± 376.3
AUC0–∞(ng · hr/ml)6262.3  ± 3404.4
CL (l/hr/kg)0.05  ± 0.02
MRT (hr)263.7  ± 155.0
Vd (l/kg)10.3  ± 0.7

Values are expressed as the mean ± S.D. of four dogs. Parameters based on data obtained through 240 h.

  • CL, clearance; MRT, mean residence time; Vd, distribution volumes.