Pharmacokinetic Parameters | Intact | Biliary Fistula |
---|---|---|
AUC0–72(ng · hr/ml) | 1672.1 ± 158.3 | 1913.1 ± 376.3 |
AUC0–∞(ng · hr/ml) | 6262.3 ± 3404.4 | |
CL (l/hr/kg) | 0.05 ± 0.02 | |
MRT (hr) | 263.7 ± 155.0 | |
Vd (l/kg) | 10.3 ± 0.7 |
Values are expressed as the mean ± S.D. of four dogs. Parameters based on data obtained through 240 h.
CL, clearance; MRT, mean residence time; Vd, distribution volumes.