Excretion of radioactivity in bile, urine, and feces after a single intravenous administration of [14C]OA (0.25 mg/kg) to intact and biliary fistula dogs
| Time | % of Dose | ||||||
|---|---|---|---|---|---|---|---|
| Intact | Biliary Fistula | ||||||
| Urine | Feces | Total | Urine | Feces | Bile | Total | |
| hr | |||||||
| 0–24 | 7.4 ± 0.9 | 7.7 ± 1.7 | 15.1 ± 1.4 | 10.3 ± 4.8 | 1.8 ± 0.3 | 14.6 ± 4.8 | 26.8 ± 8.0 |
| 24–48 | 3.1 ± 1.2 | 8.7 ± 1.0 | 11.8 ± 0.2 | 5.7 ± 2.5 | 1.8 ± 0.4 | 8.3 ± 1.8 | 15.7 ± 3.9 |
| 48–72 | 4.4 ± 1.8 | 7.5 ± 1.3 | 11.9 ± 2.3 | 4.4 ± 1.7 | 1.0 ± 0.5 | 7.3 ± 1.4 | 12.7 ± 3.4 |
| 72–96 | 3.6 ± 0.5 | 6.9 ± 1.1 | 10.5 ± 0.9 | 3.0 ± 1.1 | 1.1 ± 0.6 | 6.9 ± 1.9 | 11.0 ± 2.2 |
| 96–120 | 3.6 ± 1.3 | 5.5 ± 1.4 | 9.1 ± 1.6 | 3.2 ± 1.1 | 1.7 ± 0.7 | 11.8 ± 1.8 | |
| 120–144 | 2.8 ± 0.7 | 5.1 ± 0.7 | 7.9 ± 1.1 | 2.9 ± 0.5 | 1.7 ± 0.5 | 11.5 ± 1.9 | |
| 144–168 | 2.6 ± 0.6 | 4.3 ± 0.9 | 6.9 ± 0.3 | 2.4 ± 0.6 | 2.0 ± 1.2 | 11.3 ± 2.0 | |
| 168–192 | 2.4 ± 0.9 | 4.1 ± 0.7 | 6.5 ± 0.4 | 1.9 ± 0.9 | 1.6 ± 1.2 | 10.4 ± 2.7 | |
| 192–216 | 2.5 ± 0.8 | 3.4 ± 0.7 | 5.9 ± 1.2 | 1.5 ± 0.9 | 1.0 ± 0.5 | 9.4 ± 2.0 | |
| 216–240 | 1.6 ± 0.6 | 3.0 ± 0.4 | 4.6 ± 1.0 | 1.1 ± 0.2 | 1.0 ± 0.3 | 9.0 ± 2.3 | |
| 0–72 | 14.9 ± 2.1 | 23.9 ± 3.6 | 38.8 ± 3.2 | 20.4 ± 8.8 | 4.6 ± 0.3 | 30.2 ± 7.0 | 55.2 ± 14.9 |
| 0–96 | 18.5 ± 2.6 | 30.8 ± 4.4 | 49.3 ± 3.4 | 23.4 ± 9.9 | 5.9 ± 0.6 | 37.1 ± 6.0 | 66.4 ± 16.0 |
| 0–240 | 33.9 ± 6.1 | 56.2 ± 7.2 | 90.2 ± 5.2 | 36.4 ± 10.8 | 15.0 ± 3.9 | 88.5 ± 18.2 | |
Each value represents the mean ± S.D. of four dogs.