Pharmacokinetic parameters of CP-154,526 after p.o. (13.7 μmol/kg) and i.v. application (2.7 μmol/kg)
| Application | Parameter | Unit | Mean ± S.D. |
|---|---|---|---|
| n = 3 | |||
| Oral | C max | nmol/ml | 0.101 ± 0.035 |
| T max | h | 3.3 ± 1.2 | |
| AUC | nmol/ml · h | 1.70 ± 0.19 | |
| Bioavailability | % of dose | 27 ± 6 | |
| Intravenous | AUC | nmol/ml · h | 1.28 ± 0.13 |
| C 1 | nmol/ml | 0.303 ± 0.054 | |
| λ1 | l/h | 0.803 ± 0.060 | |
| C 2 | nmol/ml | 0.012 ± 0.002 | |
| λ2 | l/h | 0.0146 ± 0.0048 | |
| t 1/2,1 | h | 0.87 ± 0.07 | |
| t 1/2,2 | h | 51 ± 15 | |
| CL | ml/min/kg | 35.9 ± 3.6 | |
| V0 | l/kg | 2.55 ± 0.39 | |
| Vss | l/kg | 105 ± 30 |
t1/2,1, first half-life;t1/2,2, terminal half-life; V0, volume of initial dilution compartment.