Time | Plasma | Cortex | Striatum | Cerebellum | Hippocampus | Hypothalamus |
---|---|---|---|---|---|---|
0.08 | 3.51 ± 0.38 | 1.60 ± 0.23 | 1.16 ± 0.26 | 2.46 ± 0.452-a | 1.41 ± 0.42 | 0.86 ± 0.34 |
0.17 | 1.96 ± 0.30 | 1.29 ± 0.04 | 1.07 ± 0.12 | 1.82 ± 0.242-a | 1.18 ± 0.08 | 0.95 ± 0.24 |
0.33 | 1.38 ± 0.28 | 1.68 ± 0.26 | 1.25 ± 0.21 | 2.29 ± 0.562-a | 1.39 ± 0.36 | 1.09 ± 0.172-a |
0.50 | 0.99 ± 0.28 | 1.37 ± 0.33 | 0.90 ± 0.21 | 1.53 ± 0.48 | 1.03 ± 0.30 | 0.75 ± 0.362-a |
1 | 0.37 ± 0.05 | 0.91 ± 0.17 | 0.63 ± 0.19 | 0.89 ± 0.17 | 0.72 ± 0.09 | 0.29 ± 0.102-a |
2 | 0.16 ± 0.04 | 0.35 ± 0.08 | 0.38 ± 0.08 | 0.37 ± 0.07 | 0.36 ± 0.09 | 0.16 ± 0.132-a |
4 | 0.05 ± 0.03 | 0.09 ± 0.04 | 0.05 ± 0.04 | 0.10 ± 0.03 | 0.08 ± 0.04 | 0.04 ± 0.01 |
AUC | 1812 ± 346 | 2393 ± 459 | 1877 ± 457 | 2742 ± 606 | 2060 ± 548 | 1154 ± 505 |
↵2-a p < 0.05 concentration significantly different from the other brain tissues.