Table 2

Concentration of CP-154,526 in brain tissues after i.v. application of 10 μmol/kg (nmol/ml or g tissue, mean ± S.D.; n = 3–5)

Time	Plasma	Cortex	Striatum	Cerebellum	Hippocampus	Hypothalamus
0.08	3.51 ± 0.38	1.60 ± 0.23	1.16 ± 0.26	2.46 ± 0.45^2-a	1.41 ± 0.42	0.86 ± 0.34
0.17	1.96 ± 0.30	1.29 ± 0.04	1.07 ± 0.12	1.82 ± 0.24^2-a	1.18 ± 0.08	0.95 ± 0.24
0.33	1.38 ± 0.28	1.68 ± 0.26	1.25 ± 0.21	2.29 ± 0.56^2-a	1.39 ± 0.36	1.09 ± 0.17^2-a
0.50	0.99 ± 0.28	1.37 ± 0.33	0.90 ± 0.21	1.53 ± 0.48	1.03 ± 0.30	0.75 ± 0.36^2-a
1	0.37 ± 0.05	0.91 ± 0.17	0.63 ± 0.19	0.89 ± 0.17	0.72 ± 0.09	0.29 ± 0.10^2-a
2	0.16 ± 0.04	0.35 ± 0.08	0.38 ± 0.08	0.37 ± 0.07	0.36 ± 0.09	0.16 ± 0.13^2-a
4	0.05 ± 0.03	0.09 ± 0.04	0.05 ± 0.04	0.10 ± 0.03	0.08 ± 0.04	0.04 ± 0.01
AUC	1812 ± 346	2393 ± 459	1877 ± 457	2742 ± 606	2060 ± 548	1154 ± 505

↵2-a p < 0.05 concentration significantly different from the other brain tissues.