Coefficients of the regression equations for liver microsomes of nontreated and 3-MC-treated rats
| Descriptors | Coefficient | |
|---|---|---|
| log RLM | log 3-MC | |
| Constant | −3.294 | −2.852 |
| (log P)/V | 0.472 | 0.480 |
| pK a | 0.773 | 0.708 |
| Spo | −0.427 | −0.255 |
| Upo | −0.058 | −0.063 |
| Sp | −0.054 | −0.020 |
| Sd | 0.011 | 0.035 |
| Up | 0.114 | 0.104 |
| Ud | −0.030 | −0.014 |
| HDo | −0.332 | −0.266 |
| HDp | −0.398 | −0.422 |
| HDd | −0.069 | −0.024 |
| N+ | −0.674 | −0.696 |
| O−p | −1.967 | −1.801 |
| O−d | −0.243 | −0.358 |
| pK a 2 | −0.045 | −0.041 |