Table 1

Kinetic parameters for the ring methyl oxidation and N-deethylation of DEET by pooled HLM, RLM, MLM, and DEET treated mouse liver microsomes

	BALC (Ring Methyl Oxidation)		ET (N-Deethylation)
	K_m	V_max	CL_int	K_m	V_max	CL_int
	μM	nmol/mg protein/min	10⁻⁶/mg protein/min	μM	nmol/mg protein/min	10⁻⁶/mg protein/min
HLM	67.6 ± 4.2^b	12.9 ± 1.6^a ^b	191.5 ± 15.4^b	842.5 ± 49.9^b	20.5 ± 3.4^a	24.4 ± 5.1^b
RLM	38.3 ± 0.2^a	17.6 ± 1.2^a	461.3 ± 23.5^a	214.3 ± 26.1^a	19.2 ± 2.8^a	89.5 ± 10.9^a
MLM	43.4 ± 0.6^a ^b	6.8 ± 1.4^b	156.8 ± 23.8^b	660.6 ± 59.5^b	14.5 ± 2.9^a	21.7 ± 3.9^b
MLM^1-150	42.6 ± 13.6^a ^b	16.4 ± 3.4^a	385.1 ± 52.6^a	630.9 ± 128.0^b	22.9 ± 2.9^a	38.3 ± 5.1^b

Means in the same column followed by the same letter are not significantly different (P < 0.01). Values are the mean ± S.E.M. (n = 3).

↵1-150 DEET treated animals LD₁₀ (200 mg/kg/day).